Does anyone have a solution to the “Not Responding ” bug in Windows 7?

It does not matter if I open internet explorer, Windows Explorer, Word, Excel, or play a track in say Total Recorder Windows 7 Pro sits and does nothing. Just the stupid little circle thing goes around and the title bar of whatever I’ve opened displays “Not Responding”. I’ve checked for viruses malware spyware et al. I’ve run Diskeeper, I’ve stopped Superfetch, delayed its start-up all to no avail. It’s almost like the whole system is suffering from alzeimers and it has forgotten what you requested it to do.
Help please

Randi