That being said, if a weak encryption algorithm is used, or the key is left somewhere a site cracker could find it, then decryption is possible.
In general, don't leave default settings on your database, webserver, and other applications. Follow best practices for the platforms and lock everything down. This stuff is extensively covered aside from official software documentation. People make a living addressing a writing about these security issues.
Critical: If this db has a public interface, you must sanitize query strings to avoid things like buffer overflow attacks.
Whether hosting the site in-house, or with a web host, you also need to make sure the administrative interface is secure, and definitely not a known-vulnerable version.
That's the short version. When looking up information or asking further questions, be specific about the software you are using. Version and patch level matters, so have that info handy when diving in deeper.