I can’t double click no matter what mouse I use

I have searched the internet high and low to why my double click only works the first time I use it after starting my computer and then stops. I have tried several mice and it is the same for all of them.

Please oh please can somebody help me? This is my last resort before reformatting my whole hard drive (which I have already done that 4 times this year and it’s a NEW computer!)

I use Windows XP Pro if that helps at all.