My Laptop Running Vista will only run in Safe Mode!

My laptop will currently only work in safe mode. When I boot it up, everything runs as normal until the Welcome Screen. After Vista welcomes me back to my computer the next screen should be full of my icons, windows sidebar, etc. However, the only screen I see is the shade of blue that is the background color that is normally behind my icons. I have tried system recovery many times, that has not worked. I have ran virus, anti-spyware, malware, etc, and everything comes back as normal. I have defraged, condensed my registry, and even tried a disk clean up. I am at a loss. Can someone help?