All usb devices become unavailable after I use the pc very shortly

So after cleaning the dust off my pc, its been acting very weirdly. After used a little bit the pc continues to work but all the usb slots become unavailable and the “plugged off” sound starts coming. When i restart the pc i can use it again for a short amount of time but the same thing happens. Now when i try to open it, a red light appears on the case on top of a bulb icon( note that it doesnt blink or anything it stays on ) What does this indicate?