Setup.exe will not run

I have a windows 2000 domain controller with SP4 on it. I am trying to install IBM Client Access Version 4 Revision 4. When I clik on the setup icon nothing happens. I have tried installing from a command prompt and still nothing. I can take the same install files and run the setup on any other PC or server, just not this one. The files are on the desktop of the server so it isn’t a cdrom issue. I don’t get any errors in the event viewer concerning it either. If anyone has any ideas I would appreciate it. Thanks.