If you are in the debugger in VB, help will not display. The VB interpreter appears to be used to run the help.
Otherwise, there is a possibility that the registry is corrupted. My experience with Microsoft Assistance in this area was less than stellar, but you could give them a try if you have a couple of days (or weeks) to spare.
READ EVERYTHING BELOW:
Otherwise, back up everything, be careful of your email, it is hidden,, so you will need to do a full system backup to save it. Check the backups to make sure your files and email are all there. Some backup utilities do not save hidden files. Check for the c:\documents and settings\*\local settings\*\*\*\* are all there. To verify this, you need to set the folder options to show all files, including hidden and system files prior to checking the C drive and in the backup folder as well. This is vital or you will lose important data. Exercise great care, because once you format the disk the information is gone forever from the C drive.
Once you are sure you have everything backed up, reformat the disk, and reinstall the software. Then reinstall the user data ONLY from the backup disk(s). DO NOT REINSTALL the OS or programs from backup. Those bits are the problem.
It is not my fault if you lose data. You have to take responsibility to check the backups thoroughly. (which should always be done anyway.)
Regards,
Les H