unable to run applications in win 2003

I just bought IBM machine that came with windows 2003 enterprise edition. I have been able to migrate all my NT accounts to it. It is now my domain controler. Everything is working OK. I have created a shade and copied a program from the NT server to the win 2003 server but nobody is able to run the program. It tries to open but finally, we get the message ” you do not have permission to open this file. I think the permissions are OK because, everyone has full control on both the program and the share.
Please help.