Whats wrong?

I am using windows xp and recently got a problem which is whenever i try to import something from freehand or anyother software that program stuck and cant closed by any means even not by task manager. Some programs also stop working like I.E., Outlook, etc. System restore has been turned off & unable to turn on now. Everything messed up & i cant figure out that whats wrong. Can anyone help me or suggest me what to do?