Windows 10 – How do I install programs on a separate drive?

Hi
How do I get Windows 10 to install programs on a separate drive?

My new PC has 2 SSD drives – C is for Windows 10 and E is for programs.

I changed the registry settings for Program Files and Program Files (86) to drive E.

Programs still install on C.

Also when new programs are being installed, Windows 10 does not give me the option of changing the location.

What am I doing wrong?

Thanks