Can no longer get on my business website- Desktop only

This one is baffling me;

As of Wednesday, 11/7/07 I cannot get on my business/marketing website from my desktop only. This is the Only website I can’t get on.
I can get on my site with my laptop with a wireless connection in the same room as my desktop. My friends can get on my site from their desktops across the country.

I have IE 7.0 and have had no problems with this at all up until this date. I have also tried to get on my site with FireFox to no avail.

I have done;
1. dns flush
2. deleted all history, cookies, etc.
3. run all spybot and registry programs to fix.
4. called my IPS with no help at all

My desktop is not picking up the website at all. Could their be some kind of coruption problem?

Any help would be greatly appreciated!

Mark