Enterprise Anti-Virus and Anti-Spam Solutions

I admin a rather complex network of machines and users and for some time have been using Trend Micro ServerProtect and OfficeScan for my Enterprise products and PC-Cillin Internet Security for computers that are stand-alone (not connected to the corporate network).

I also consult for outside firms that use Symantec products.

Trend Micro has gotten so cludgy, especially the PC-Cillin product, that I am on a quest for a new solution.

What solutions are available that are robust enough, and centrall managable, that would fill my needs.

I’d liek to know what others are doing, especially any feedback from current or former TM users that have switched or are thinking about switching to a new product.