Anyone out there uo to a virus removal challenge?

I need help BIGTIME. I have come across the nastiest virus or combo of virus’s that i have come across. I am trying to avoid the “fix-all” of doing a wipe and starting from scratch.
Vcleaner and antivirus softwares will download but when run, ever so breifly a command box pops up and goes away, and nothing happens.
System restore- when trying to run it get the “System Restore turned off by group policy” crap. Deleting Policy Key thru REGEDIT had no effect.
Comp is running Vista ultimate. Greatly appreciate anyone willing to help me straighten this out