oh man...been there..done that and it aint pretty!
I recall working for a public sector gov't agency in which they had an entire graphics department with some real hard ass Mac users who simply refused to have a PC on their desk
We were forced to buy a Mac version Novell client from a 3rd party vendor called ProSoft in order to get Macs to communicate to the Netware servers with NCP packets over IP
Appletalk should be avoided like the plague because it I have seen it cause broadcast storms on the network and is just a crappy protocol to begin with
If you can stay with pure TCP/IP, then that is the way to go.
Netware 6.x now has a feature which allows itself to emulate a Windows or Unix server by running either the CIFS or NFS protocol, so Windows or Linux/Unix clients do not need to have the Novell client installed to communicate with the server. Macs on the other hand are in their own world and would probably need their own Novell client. Check out http://support.novell.com to see if they have a Novell client for the Mac. I know they got one for Linux.