Blot in System32

I have a number of files in my system32 directory that are causing my system to bog down with too many of these files. Is there a way for me to remove these? The files are sequnetially numbered and begin with Reg022 and so on. I am running IIS4 on this box and have several domains on it as well. If I cannot get rid of them how do I put them to a different drive. The drive they are on is only to be used for system files with all other programs running on different drives. The drive is 2 gig in size which was the recommended size partition per Microsoft. Currently these files amount to almost 1.4 gig of space on the drive. With just the system on I am running out of space fast. Help is appreciated to rectify this problem.