We have used Autoprof's Profile Maker for the past four years in an environment with 10 servers and 300+ users. In addition, using only print drivers that have been thoroughly tested (HP, Canon, etc.) and keeping the variety of installed printer drivers to a minimum. Sounds like you may know from first-hand knowledge that nothing can crash a Citrix server quicker than a faulty, poorly written print driver.
We have drivers installed for HP (laser jets) and Canon (digital copiers). Everything else gets the Citrix PCL4 Universal Print Driver.