Corrupt signatures with Outlook 2010 and Roaming profiles

Greetings and salutations.
We have started running into a situation where users cannot add/edit/delete existing signatures in oulook 2010. Users are on roaming profiles with physical equipment (I have not noticed this on any of our VM users, yet).
We are getting a simple error stating ‘A file error has occured’ and giving the location of the file. Ex. (\\servername\user\filename.htm)
Currently we are dealing with the issue by deleting roaming profiles on the server and physical machine. What I’m looking to see is if there is an easier way of dealing with this problem, with the hopes of preventing it in the future.

Thanks in advance.

Sean