Home Page cannot be changed

Home page keeps going back to:
http://any-find.com/index.htm
One of these rogue sites I guess. Obviously I can change it from Tools>Internet Options>Home page, etc. but on a reboot the homepage goes back to above.
Have tried Ad-aware (ver.) and Spybot (search and destroy) to no avail. Or maybe I have not been using these softwares properly. There is no problem entry in the Run area of the Registry. If someone knows a better way please let me know. I will try anything at this stage!
(using wins 2000, SP3, no recent updates)
Thx in advance…