Installing .msi files using a GPO

I am attempting to deploy Windows Defender with a GPO in a large AD forest. I am trying to find out what directories are available to store and call the .msi file from. Thus far, I am only able to deploy it if I have the file located on our primary domain controller and this will eventually cause replication issues. I would like to install from a one of our application servers but so far I have been unable to make it work from that location. I am using a fully qualified path also if that helps. I have also placed the call order after any drive mapping.

Thanks