ISA 2004 SP2 – Error 400 on many sites – HELP

I have an ISA 2004 SP2 with KB 916106
http://www.microsoft.com/downloads/details.aspx?familyid=2AA53EE6-527C-4398-AB7C-FCF8E8DDE8CE&displaylang=en

The problem i have is that far too many sites are not comming up due to error 400. After investigation it seems that the ISA server is changing the header such that it tries to get to the site via ip address rather than the URL.

This is happening on far too many sites now…

What can i do… a PM reply to rishi.shah at anite dot com would be very much appreciated of you have a solution.

I have disabled the compression filter, caching compression content filter but still no joy.