losing folder permissios

Something has gone awry on my server 2003 and XP network NTFS security. Recently any changes to security rights on any folder will revert back to its original settings even if I disable inheritance. It does not happen right away but will eventually happen. I don?t know what?s causing it and why. My knowledge of Server 2003 and NTFS security is very basic and any help would be greatly appreciated since this is creating havoc with some software and user rights.

Thanks in advance,

JC