Protect Files Fro Virus Scanners

Is there a way to shield certain files from Virus Scanners? I use some “hacking programs” from time to time, but on certain computers the real time virus scanner will delete these files. I know some virus programs allow you to create exclusions, but I work on over 100 systems and most have different anti-virus software. I know I could put them on a CD (read only), but I do not want to be carrying around a CD everywhere. USB drives are easy to update and much more mobile! Thanks for your help!