REMOVING ADWARE & SPYWARE

is there any more ways on how to get rid of spyware and adware on my computer?Coz i tried using adwareSE from lavasoft both on normal and safe mode but still i have the spyware and adware on my machine. It did remove some but still i have 2 to 3 more on the machine. Aside from reformatting is there any other way?