Terminal Server, QuickBooks, Admin rights

I have a Win 2K3 Server with the following roles established: File Server, App Server, Terminal Server, Domain Controller, DNS Server. The last two (DC, DNS) are to provide backup for another W2K3 server that is the primary DC/DNS server.

We use this server to provide remote access to our QuickBooks application; remote users use Remote Desktop Connection to run QuickBooks on the server. QB, however, requires that the use have some admin rights. Other than making the remote individuals Administrators, I have not been able to find a set of folder-specific or Power User permissions that will work, but, of course, making them Administrators is not a good idea.

Can anyone offer suggestions?