What can I do to stop spam

Just recently, three users on our network have been receiving a lot of spam e-mail. This morning I walked into 65 e-mails all crap. Let me take this time to point out I rarely give out my e-mail address in fear of this exact event happening. So, I’m in Washington state, and I’ve registered with WAISP. How and/or what do I do now? Thanks………………..