Windows SBS 2003 permissions help

I am setting up a Windows SBS 2003 R2 server to host a point of sales application for a family owned store. When I try to run the software from the workstation logged in to the domain as a user the program wont run. When I try it as an admin it runs just fine. I have set folder permissions to allow users full access to the folder and program. I am not a tech pro I am just the one at this family owned business that was lucky enough to be given this task… Any help would be wonderfull!

Tucker