XP Pro has a mind of its own

Two people in my area with XP Pro on their laptops have a situation recently where screens change, drop down menus open and close and different options are selected all on their own. Virus definitions and scan are as of 10/2. The mouse has been replaced on both when in the docking stations. It happens a few times a day and has been witnessed by the IT people. Others with XP do not have this problem. The IT people’s solution is to ‘rebuild’ XP Pro rather than just reinstall it. It’s not that we don’t trust them, it’s just that they don’t sound sure of themselves about it. Does anyone recognize and have suggestions for this problem? Thanks for any assistance.