Before you go any farther, this is a profile issue. The run-time is unrelated, but the Active X one is. To try it out, open Control Panel-Passwords. Go to the User Profiles Tab and select the "Users Can Customize Their Preferences And Desktop Settings" option. Delete all .pwl files on the local drive and reboot. This will create all new profiles and I bet you your error will go away.
NOTE: If you do not want to enable multi-profiles, try to delete the .pwl files anyway. This will reset your all your desktop settings back to default. As far as the run-time error, I don't know where to take you without some more info. What program is it??? Is it recent???