While I've only used one I had massive problems with a Dual Athlon Tyan M'Board setup that was put into a Mission Critical Business application because the owners Son was in a CS course and insisted that AMD was the way to go. We never really solved the problem properly but eventually because of the cost in lost production I replaced the M'Board with a Dual Intel unit and the son took the AMD one to play with.
But in an attempt to make it work half way decently I would suggest that you do the same as I did Flash the BIOS to the Latest Available, carefully go over any Windows Patch's that have been applied and remove what you can there are some known problems with USB and some of the latest Patches released by MS, and if this is a fresh install you may have installed one of the problem patches.
Remove one of the CPU's and see if you get a more stable platform to work from. I found this cured a lot of the ills that I ran into though it wasn't a real fix but it did allow the system to work till I could replace it.
Check all of the RAM installed and make sure that it is all of the same make and type as I had a lot of problems with that, the owners son insisted on installing some no name RAM and it didn't work at all well with the Cosair RAM that I had installed. If nothing else works reduce the unit to the minimum number of RAM Sticks that it will work with and make sure that they are exactly the same make and type and attempt to get the datta off the system that way. If that's what you are trying to do that is.
If you have the 64 Bit version of Windows loaded replace it with the 32 Bit version it works much better.