If you can get your AV & Spy Ware Programs updated can you access these functions in [b]Safe Mode?[/b]
If not I would consider removing the HDD fitting it to a USB caddy and then saving all your data from that drive if you haven't already done this and then wipe the drive with something similar to Boot & Nuke available for download here
http://tinyurl.com/4rfur
This writes zeros to every sector of the HDD and deletes any infections that are on the drive but also any data that you have stored there so you need all your data backed up first. If you have encrypted any of your data you'll need to save the encryption Keys as well and the directions for doing that are listed here
http://tinyurl.com/orpmf
or you can do an in place install following the directions listed here
http://tinyurl.com/g4bv8
But if you already have an infection just doing an in place install will not cure your existing problem.
You may be able to clean out the drive by fitting it to a USB caddy and running both AV and Spy Ware Scans on it on a different computer that is well locked down but even still you run the risk of infecting that machine depending on what you have caught. This should be very unlikely but you need to know this before you start and have everything important backed up so if necessary you can just Blow Away the Installed Software on that other computer and reinstall it all from scratch on both computers.
I've been there done that and it's painful when it happens.
Col