Assuming 1) your imported tables are not linked back to access AND 2) the drop down boxes are created with Data Validation in Excel.
You will need to re-establish the logic that you built into Access whereby the content of the second list is dependant upon the choice in the first list. The cells used for validation can have formulas so they become dynamic lists
Eg: use a lookup or IF formula in the data validation cells of the dependant list(s).
If DROP DOWN 1 = A or B
Use a Lookup table: (say cell R1C1 to R4C2)
A C1
A C2
B C3
B C4
To only show options available for the choice made in Drop Down 1 - your DROP DOWN 2 VALIDATION CELLS should refer to this lookup table using either the IF formula based on selection in drop down 1 (OR a LOOKUP formula using drop down one as the lookup value).
If user can then go back and change Drop Down List 1 you may need a macro to check/force update of the dependant cells before completing the data entry.
Result -
IF A selected see only C1 and C2 OR
if B selected see only C3 and C4
Note if you have different length lists, Eg: option B requiring a third C5 value, you will need to manage any blanks in the shorter validation list for A - I have not looked into how to do that but may not be an issue is you have some blanks?
You may also have to control the users so they go through the drop down lists in the correct order.
Hope this helps.