Hi User Deleted,
The client connects to a port that is blocked or unavailable on the mail server. If the client is attempting to send a message, the blocked port is 25, if the client is attempting to retrieve a message, the blocked port is 110. Refer to the error message for the protocol and port numbers
Open a command prompt on the Exchange Server computer. You need to modify the command prompt properties, because the data scrolls off the screen.
At the command prompt, type netstat -an. Scroll back to the beginning of the data output, and look for the following entries.
Proto Local Address
TCP 0.0.0.0:25
Foreign Address State
0.0.0.0:0 LISTENING
Proto Local Address
TCP 0.0.0.0:110
Foreign Address State
0.0.0.0:0 LISTENING
If these entries are present, Exchange Server is listening on ports 110 and 25 on all interfaces. This is normal. If these ports are not available, you may need to further troubleshoot the following services or systems. The following general causes may "hold" these ports, or make them unavailable:
The Exchange Server information store service is not running, or the POP3 protocol is not enabled and listening to port 110. Verify that the information store service is running.
The Internet Mail Service is not running or is not listening on port 25. Verify that the Internet Mail Service is running.
A proxy server located between the client and the server may be blocking access to these ports to the Exchange Server computer.
Another application, such as virus-scanning software, has reassigned port 25 to another port. Disable all non-essential services, including antivirus software, and then restart the server
Hope it is usefull for you,