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User Permission to run application in Client

By jeni.cs ·
I have 300 users running on win2k3 domain, Now my requirement was to give permission to users to run specified - custom develpoed applications. If add these user groups to local admins group, they are able to work on application. My question is, will the group policy settings done at domain level will effect after this, if not what I need to do to restrict some previlage.

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