In this paper, the author’s present CMOS sense amplifier has been studied and their performance evolution in terms of sensing delay and power has been carried out. The circuits have been implemented in 0.35μm and 0.5 um CMOS technology using mentor graphics tool. Comparison of existing CMOS sense amplifier and modified current sense amplifier has been reported. The comparison has been made in term of power dissipation and sensing delay of the circuits. The effect of various design parameters on the current sense amplifier has been discussed and reported.