Can I use COA2?

PC Magazine has a down load called COA2,whitch notifys windows when you change the location of a program. I want to no if I can install COA2 on my second hard drive whitch is G. Will the program still work the same. does it matter what harddrive it is down loaded on. PLease get back to me as soon as possible at wwwfluffy@new.rr.com Thank you