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Cannot write to my program files directory

By domhever ·
I have a program files directory on my e that I use to install most of my applicaitons to as it is much larger than my c partition.

However I cannot write or delete anything from this folder now, and I cannot open an application I have been using for ages either, and this is how I noticed it. I have scanned my machine using Panda Titanium 2007 and Adaware, and nothing suspect shows up but I presume it is something malicious. I am not an expert at reading Hijackthis logs although I have fixed something in the past using this, and my hijackthis log looks ok too from my knowledge.

Has anyone got any ideas? It is only this directory that is giving me trouble and today is the first time this has shown up.

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