Need more info, ie Operating System, and what you are trying to run, are you getting a error, not enough conventional memory to run application, if so you will need to load some of your device’s into High Memory, using the DeviceHigh= instead of device= in the config.sys, and remove any uneeded items from the config.sys and autoexec.bat, run the MEM command from dos and it will inform you of what memory is being used.
The above is true. Also use LH for Load High in your autoexec.bat file for some of the things in there. If you want it all done automatically for you, run the DOS utility called MEMMAKER if it is on your system.
Memmaker will accomplish what you need to do.