Deleting a folder on 2nd drive

There is a file that is locking up my system whenever I access it. I am trying to delete the folder it is in. Trying to do this my system locks up. I went into dos (from a boot disk) but I am unable to see this drive, only the master drive.
WinXP SP1 intel 650mhz generic computer 512 megs ram. Have run adaware and spybot, anti virus hangs up on this file. This started 2 days ago. I tried a linux boot cd but am unable to see the 2nd hard drive.
Any ideas?