Exchange Email Server.

Only at the expense of a healthy Exchange server. Most references warn against manually deleting (or moving) files from any of the Exchange folders.
The files in this folder are either the Information Store databases (priv.edb and pub.edb) which are the meat of your Exchange organization, or transactional database files (edb.*, *.edb, and *.log). Both the Information Store database files and the transaction database files are required to recover from a system glitch. If you delete the transaction database files (which are probably the old files you are referring to), your system will not be recoverable.
I would suggest conducting online backups (if you're not already doing so) which will automatically delete unneeded transaction database files. If you are already doing online backups, they are not completing successfully.

Additional to previous answer - On the other hand, if you are not doing on-line backups but are doing off-line backups (I certainly HOPE you're doing one or the other), you can enable circular logging on your Exchange Server - this will minimize thenumber of log files that are created and retained in the data folders. This is done through the Exchange Administrator program in the Server properties, Advanced Tab - put a checkmark in both boxes. Hope this helps!

Use the ESEUTIL in the bin directory on the systems directory on your Exchange server. Before you do so check Microsoft TechNet and Exchange books online help files for further information about its use.

It is dangerous to do this manually as youcannot be sure which data is committed to the database and which is not.

Use the ESEUTIL in the bin directory on the systems directory on your Exchange server. Before you do so check Microsoft TechNet and Exchange books online help files for further information about its use.

It is dangerous to do this manually as youcannot be sure which data is committed to the database and which is not.

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