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This question is a little broad, so I may need more information. But I will try and answer your question.
If you have an internal mail server with IP address 10.0.0.2, and are translating that to a real public IP address of something like 18.104.22.168, then mail sent to 22.214.171.124 will go to your internal mail server. If you have a firewall, you are going to have to make sure port 25 is open inbound to your mail server, in most cases to the public IP address.
For mail to be sent to your domain (i.e. domainname.com) you will need to have an MX record for your mail server registered with your DNS.