Hi
1- You said that you Swapped the hard drives in to PC when you DO that if you are using deffrent OSes then you may have a problem with drivers for devices since there are defirent drivers for diffrent OSes on the otherhand if the devices are deffrent then you also may have problems too.
2- You said that the mouse not working is faster does that mean they are deffrent type and brand. This will lead to the question are they using the same port. (Serail,or PS2 or USB) if they are deffernt ports maybe that port is disabled form the one not working check your device manager for error or a yellow "?" .Remove then install the device then rebbot.
plase comment in your qestion about your OSes, is the PC are the same hardware and the mices which type (Serail,or PS2 or USB).
Good luck
Mohamed