Hardware

You didn't provide any details of what you have tried so far. For a problem like this, my first response is to power down completely for at least ten seconds (not just restart) and then turn it back on and watch for error messages on bootup. Usually, reloading from a cold start will reinitialize all of the I/O ports and things will start working again. If not, then there may be hardware I/O problems to troubleshoot. With two different I/O modes going out at once, I'd suspect reinitialization might do the trick. Have you noticed any power glitches lately? They can scramble the settings maintained in memory.