I need a little more information, what kind of PC do you have? All mother boards are different, you/me/anyone would need the model to look up the manual...
**On the back of the drive there are jumpers... I always set everything to CS (Cable Select) makes it easy so I don't have to give it much thought... The only thing I could think of as far as jumpers on the Mombo, that would affect the drive is a jumper that would change the data rate from ATA100 to ATA133 vise versa....
What exactly is happening? cause I doubt changing jumpers on the Motherboard will fix your issue... On the drive, could be your issue...