Real-time AV on Servers?

We are using Symantec AV version 10 on all servers and workstations. We are trying to gain support for a task to disable the real-time scanner on all servers except for file & print.
We’ve noticed through the years that SAV real-time scanning can cause major application problems and performance degradation.
Over the years we’ve set up scan exclusions for Exchange and domain controllers, but it seems like every server needs a different set of exclusions.
Those of you with a corporate antivirus solution: how is this configured on your servers? Do you have real-time AV scanning enabled or disabled? Why?