Removable HDD

I have a user that travels quite a lot and would like to stop carrying a laptop. A possible solution for it is that he may have a clone of his laptop configuration on a removable hard disk drive. My concern is that he does not want to keep a fixeddisk in any machine after cloning to the removable disk.
I thought that maybe by connecting the Removable HDD to a USB and booting the machines to a bootable floppy could be done. Has anyone done this before?
Is it possible with Windows 2000 Pro?