Software problem and domain

Hello learned ones. I have a problem (don’t we all) with some software that is not there until the workstations log onto the domain. This software is an access based program with a delphi frontend. When you log in locally it all works but when you log onto the domain parts of it, notably printing parts don’t. As this is a new win2k3R2 server that has been installed – it was all on NT4sp6 before, no probs – the group policy is the default. I have trawled through this but cannot see anything amiss (I might add here that I am self-taught-still-learning this behmoth). Has anyone any idea why this might be going on. What am I missing/not doing. Thank you.