Unable to read CD-ROM contents

All computers are virus free and the operating systems are up to date:

I am attempting to load a cd on only 1 computer, a W2k desktop. The problem is that the computer acts as if the cd is not in the drive when of course it is. The cd is new. I am unable to view the contents of the cd, not only on the W2k pc, but when I put it in for a test an XP laptop as well. The XP laptop and W2K pc are able to read other cds, just not this one. The final twist is that an XP desktop (the 3rd pc)is able to read and install the CD but this is a work computer, no games allowed. Help!!!!!!!!!