addresses are rarely GUESSED except in the case of Admin, Suport etc. Most are gathered by web crawlers that search websites for email contact addresses. Once the sender doesn't get a reply, he can asume it's genuine and work to get you address book.
Once your addy book is spoofed, everyone gets an email from you. MOST of the time when someone uses YOUR address to relay mail, this means you also have a virus or worm to get rid of. THis is of course unless someone else has you address and they were spoofed themselves, in which case you are usually next in line.
I have my client's SPAM protection set up and so finely tuned now that nobody in their organization sees more than 2 perhaps 3 junk emails per day, they were receiving hundreds each at one point.
As for shutting off the Auto responders, well you're right, unless it's a vacation alert, I don't want it back.
As for shutting off RELAY, well I would hope NOBODY still has mail relaying active on their network, but then again, it is suprprising how many fortune 500 companies are blacklisted as they won't resolve their meial relay issues themselves. they are the headache that we face each day, mail relays from spoofed company servers run by morons who haven't even heard of security.
NEC couldn't send me email until I told them to fix their damn servers, same as Telus and Nortel Networks. Network engineers on a blacklist, whatever next?