Windows 2000 and Legacy USB Support

I have a computer running W2K and if I enable Legacy support in the bios nothing usb will work. If I disable legacy support my printer and usb mouse will work, but if I disconnect them they have to be re-installed. Digital imaging devices will notwork at all. Device manager see them, but there user interface software doesn’t find them. Any sugguestions.

The board is a MSI – 5169 running the latest drives and bios from MSI.