Desktop

Are you sure the mice are serial mice?

Most new mice no longer support serial port connections even with an adapter.

If the mouse does support serial port mode, make sure that you have the correct adapter.

Next, are the COMM ports enabled in BIOS settings, and do they show up in Device Manager?

Chas

if its hooked up to serial port make sure that the serial ports are enabled in bios in middle school we always disabled them before people we didnt like used them

Check you bios setup, its more than likely that you do not have the plug and play option turned on. Check to see if thats it if not try reinstalling you operating system.

Check you bios setup, its more than likely that you do not have the plug and play option turned on. Check to see if thats it if not try reinstalling you operating system.

Check you bios setup, its more than likely that you do not have the plug and play option turned on. Check to see if thats it if not try reinstalling you operating system.

This sounds like an older BIOS that is Plug and Play 1.0 compliant.
In this case you have to set COM1 to IRQ 4 and the I/O to 03F8.
There were several bugs in PnP 1.0
In severe cases, you will have to manually force IRQ4 to ISA. (Also in the BIOS)
Regards, Chris

They have it right, but Earnest aka Superman, you need to have a tech look @ that Plug n Pray there Bro. Lol. You be skippin'!

whose mouse is it, Logtech? You can try installing a genric driver for the mouse if you do not have one that came with it. Was there, is there a disk with the mouse?